BISS Bioreactor Systems Modular, Scalable & Adaptable

BISS is dedicated to create new tissue engineered medical devices that replace and/or enhance tissue function that has been impaired by disease, injury, or age. BISS products are designed to assist this process at every step from Characterization of Native Tissue to Cell Culture to Evaluation of Tissue Engineered Products.

BISS's Bioreactor Series

The BISS Bioreactor Series of instruments set the standard for 3D cell culture and tissue engineering research. Available for most construct geometries, these instruments mimic the in vivo mechanical environment with user controlled loading conditions. The modular design allows for virtually limitless system configurations, ensuring that the bioreactor systems can meet researcher's needs today and in the future. Chambers and grips can also be used on standard BISS systems for seamless transition from cell culture to characterization and evaluation.

Introducing the NEW TE200 and TE500 Systems

The new TE200, TE200PB, and TE500 test instruments are designed to cover all of your tissue engineering and characterization applications.  These new systems are small enough to fit in a standard incubator for all your living system applications and powerful enough to test new combination (tissue + predicate device) medical devices.  They also allow researchers to choose the tool which fits their project as opposed to choosing a project to fit their tool.  Featuring either a 200 or 500 newton screw action motor with an integrated displacement transducer, the stimulator can be used to provide tension/compression with the LigaGen L30-1 chamber or with any of the CartiGen chambers.

These lightweight, compact, corrosion resistant construction is compliant with most bench-top incubators.

Loading conditions

Tension
Compression

Stimulator Specifications

+/- 25 mm axial stroke
+/- 200 N or 500 N maximum dynamic axial load

Dynamic Performance

50 mm amplitude @ 1Hz

5 mm amplitude @ 10Hz

2 mm amplitude @ 13 Hz

TE40 Systems

The TE40 Stimulator is a voice coil linear motor with a frictionless flexure bearing system.  Featuring a 40 newton linear motor with an integrated optical displacement transducer, the stimulator  can be used to provide tension/compression with any of the LigaGen, CartiGen, or DermiGen chambers or to provide pulsatile pressure to the LumeGen or CardioGen chambers.

These lightweight, compact, corrosion resistant construction is compliant with most bench-top incubators.

Loading conditions

Tension
Compression
Pressure
Shear
Custom

Stimulator Specifications

+/- 4.5 mm axial stroke
+/- 40 N maximum dynamic axial load
+/- 15 N maximum static axial load

Standard Bioreactor Configurations include:

LumeGen & CardioGen: Pulsatile Pressure & Flow Bioreactor

Provides pulsatile and shear stress stimulation to a vascular construct. Available in single and multiple chamber configurations with material properties feedback and control. 

LigaGen: Tension Bioreactor

Provides oscillatory axial stress stimulation to tendons and ligaments.  Available with additional stimulation axes in single and multiple chamber configurations with material properties feedback and control.

CartiGen: Compression Bioreactor

Provides oscillatory axial stress and perfusion to cartilage constructs. Available in single and multiple chamber configurations with material properties feedback and control.

OsteoGen: Perfusion Bioreactor

Provides media perfusion to bone constructs. Available in single and multiple chamber configurations.

DermiGen: Modified Tension Bioreactor

Provides oscillatory axial stress and media perfusion to skin and "skin-like"  constructs. This bioreactor system provides an air/media interface to maintain dermal differentiation. Available with material properties feedback and control.

Custom and Automated Bioreactors

If your application does not involve one of the standard tissue types above, chances are we still have built a system that is adaptable to your application. BISS also has recognized the need for scalability and automation for many cell and tissue growth studies. BISS's Series Bioreactors were designed to be scalable allowing for simultaneous multi-chamber experiments to enable translation to clinically relevant regenerative medicine. Contact us to learn more information about our automated systems.